K1 antigen-associated resistance to the bactericidal activity of serum

Role of capsule and O antigen in resistance of Klebsiella pneumoniae to serum bactericidal activity.

The ability of Klebsiella pneumoniae strains to resist the bactericidal activity of serum was quantitated. The K. pneumoniae strains tested included mutants lacking the capsular polysaccharide and mutants having a modified lipopolysaccharide structure. The last mutants were obtained as phage-resistant mutants, and their lipopolysaccharide was characterized by sodium dodecyl sulfate-polyacrylami...

Resistance of Gardnerella vaginalis to bactericidal activity of human serum.

To assess the sensitivity of Gardnerella vaginalis to the complement mediated bactericidal activity of serum, six laboratory strains were incubated with normal human serum and two strains freshly isolated from women with non-specific vaginitis (NSV) were each incubated with homologous patient serum. There was no significant difference between the number of organisms recovered from unheated or h...

Serum Bactericidal Resistance in Uropathogenic E.coli

Urinary tract infections(UTIs) are among the most common bacterial infections encountered in clinical practice (Ejrnaes, 2011)) E.coli causes about 80%of acute UTIs(Mitsumori,1998).E.coli is the most prevalent facultative gram negative bacilli in the human fecal flora, usually inhabits the colon as an innocuous commensal (Johnson, 1991). E.coli strains causing disease outside the gastrointestin...

Absent Bactericidal Activity of Mouse Serum

For Serum Bactericidal Activity against Neisseria Meningitidis

Ala’Aldeen, D. A. et al. (2000) “Dynamics of meningococcal long term carriage among university students and their implications for mass vaccination” J Clin Microbiol 38(6):2311-2316. Andrews, N et al. (2003) “Validation of serological correlate of protection for meningococcal C conjugate vaccine by using efficacy estimates from postlicensure surveillance in England” Clin Diagn Lab Immunol 10(5)...